The Influence Of Mechnical Stimulus On Endochondral Ossification In Long Bone

It has been a basic criteria that the mechanical environment can influence the skeletal morphogenesis in bone physiology. The study of bone growth is relative mature based on experimental method at the biology aspect for the present. The human bone is a complicated machine. Further more, bone is a kind of special material. Life movement form is very complex. Therefore, the experimental method is limited. Considered the biomechanics factor, the influence on the bone growth from embryo stage with the finite element method has not been reported at home.The aim of this project is to simulate the bone growth and bone configuration using ANSYS finite element method, analyze the influence of different biomechanics factor on the process of bone development further, and provide some theoretical proves for understanding bone disease caused by different mechanical environment.Based on the theory of bone development and bone remodeling at the biology aspect, combined physiological mechanism, took the second metacarpus as the study object of long bone, built three-dimension model using the finite element method, we analyze the influence of mechanical stimulus on cartilage changed to the bone. Totally speaking, the thesis includes the following parts:(1) Select and build the model. Take the second metacarpus as the study object of long bone. build the three-dimension model using ANSYS finite element method.(2) Simulate the process of the bone growth. Construct the maturation index to reflect the influence of cumulative stimulus on bone growth combining daily osteogenic index, using the bone remodeling theory to simulate bone modeling and remodeling in different phase.(3) Analyze the progress of bone growth. We discuss the process of bone growth under different magnitude loads and the biomechanics, futher more, verify the influence of mechanical stimulus on the process of bone growth. We give the optimum load conditions and biomechanics parameters for bone growth finally.The creative point of this thesis is that the algorithm of bone growth is introduced with strain energy density. The process of bone growth is simulated using ANSYS finite element method. These results are consistent with the Carter's results. The finding also matches physiology. Therefore, the algorithm of bone growth is legitimate.This thesis basically simulates the process of endochondral ossification based on the bone growth theory and bone remodeling theory. We verifies that it is approprite for bone remodeling using unit strain energy density with load history as mechanical stimulus. This project provides some valuable worth for further exploring bone growth quantificationally and enriches the bone growth theory. It helps to understand bone disease caused by different mechanical environment.