Study On Virus Genome Bioinformation Visualization System

Along with the completion of human genimics project, the key research of bioinformatics has transferred from collecting data to processing data and abstracting information.However, in the process of analyzing the DNA sequence, the traditional methods based on statistics couldn't play the strong power of people's brain in pattern recognizing. Regarding virus genome as the research object, this dissertation does some research on the common model, the construction of Z curve and the establishment of graphic database. At last, it talks about the corresponding problems in applying the model to build the NDV bioinformatics visualization system.1. The research of constructing the Z curve of nucleotide sequecnce. Through analyzing the distribution of the spatial points by T-transformed, a rarefying algorithm based on bounding box is applied to construct the Z curve of nucleotide sequence. Applying the algorithm and adjusting the value of rarefying factor dynamically, the user could achieve a multi-precision Z curve corresponded to the nucleotide sequence. Experiments have proved that this algorithm is convenient for general research on complete genome sequence and detailed research on some specific gene, and provides a new idea for homology comparison and molecular evolution study.2. The research of bioinformation visualization system model based on C/S mode. Due to the problems of data management, integration and application in the bioinformation visualization system, this dissertation firstly sums up the general process, and then gives a kind of model based on C/S mode. This model solves the transformation, the procession, the display, the analysis of nucleotide.3. The establishment of NDV bioinformation database. According to the architecture of different format sequence file, the structure of space data points after Z-transformed and the data structure of curve attribute, the NDV bioinformation database is established. Through vectorization the Z curve graph, the Z curve graphic database of the nucleotide sequecnce of virus genome is established; and then the nucleotide sequecnce database is also founded. Finally, the hitching of graphic database and nucleotide sequecnce database is made.4. The implementation and application of bioinformation visualization system. The design and implementation of NDV bioinformation visualization system based on C/S mode is the emphasis in this chapter and the system is used to display some bioinformation, to make visualization analysis of complete genome and different genome sequence.