Let W[x±1,e±x] be the generalized Witt algebra in the one-variable case based onusing the exponential functions. W[x,ex], W[x,e±x] and W[x±1,ex] be its Lie subalgebras.Kawamoto et al. determined the automorphism groups of W[x,ex] and W[x,e±x]. In thispaper, we determine the automorphism groups of two other Lie algebras W[x±1,ex] andW[x±1,e±x], the derivations of all the four Lie algebras and the second cohomology groupsof W[x,ex] and W[x,e±x]. The main results are as follow:Let W be any one of the four Lie algebras, denote by Aut(W) the automorphismgroup of W. Then Aut(W[x±1,ex])~= F? and Aut(W[x±1,e±x])~= Z/2Z F+. Denote byDer(W) and Inn(W) the spaces of derivations and inner derivations of W, respectively.Then Der(W) = Inn(W)⊕d . Let H2(W,F) be the second cohomology group of W.Then H2(W[x,ex],F) = H2(W[x,e±x],F) = 0.
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