The Theoretical Studies On The Change Of ATP's Concentration In Muscle Contraction And The Flagellar Beating

Every movement of living organisms such as muscle contraction, beating of the flagella or cilia, chromosome copy and segregation and cell division, retrospect to molecular level, refers to molecular motors. Molecular motors use ATP or GTP as energy sources and execute diverse biological functions by changing the chemical energy deposited in ATP or GTP to mechanical energy. Owing to the improvement of the biological technique, the unprecedented progress to the research of the muscular contraction property under different biochemistry conditions and the mechanism of the flagella and cilia's bending have been made. This paper is proposed to study the change of the ATP's concentration in the process of muscle contraction and the characteristics of the flagellar beating.The text is divided into two chapters. In chapter one, the change of ATP's concentration is introduced. From the viewpoint of energy circulation, the change has been studied with the chemical kinetic method. The result indicates that the concentration of ATP assumes a periodical oscillation around the equilibrium point. The biological significance of the theoretical results has been discussed. In chapter two, the structures of the flagella, dynein and the experiments and theories about them are introduced. Based on the analyzing the experiments and the theoretical model about them, we propose a model of the mechanochemical dynein ATPase cycle. Lastly, we discuss the formation of the bend in the base region of the flagella.