Expression Of Human Coagulation Factor IX In Transgenic Tomato

Hemophilia B is an abnormal bleeding disorder which results from a deficiency of human coagulation factor IX (hFIX). The gene for human coagulation factor IX is situated on the long arm of the X chromosome at band Xq27.1, and spans 34 kb. It consists of eight exons and seven introns, the cDNA and coding sequence of which is 2802bp and 1386bp, respectively. The incidence of Hemophilia B is approximately 1 in 30000 male births because it is transmitted as an X-linked recessive trait, bringing great pain as well as tremendous economic burden to the sufferers.The current treatment for this disease is infusing plasma-derived or recombinant hFIX protein, which is effective at preventing and arresting hemorrhage, but the therapeutic use of...