Inhibition Of Proprotein Convertases By Mung Bean Trypsin Inhibitor

Many peptides and proteins required the proprotein convertases to be activated after biosynthesis as precursors. Proprotein convertases (PCs) involved in many important physiological events such as the maturation and secretion of peptide and protein hormones, the maturation and secretion of membrane receptors and the activation of viral envelope glycoproteins. PCs expressed in virtually all cells and tissues, and knockout embryos showed multiple defects, some even die before birth. Here, we reviewed some resent progress on the research of PCs and their inhibitors including the relationship between their structure and function, the molecular mechanism of PCs' posttranslational modification, the role of PCs in homeostasiss and pathology and the recent findings on PCs inhibitors. These findings will not only pave the way for functional studies of the PCs but also aid the rational design of antiviral and antibacterial drugs.