Cloning And Functional Analysis Of A Novel Human Heart Development Candidate Gene HLBH

The heart is one of first organs to form during organogenesis in the vertebrate. Cardiogenesis is a very complex process and it requires precise regulation of series of genes. The identification of the molecular pathways that guide heart morphogenesis will provide a basic understanding of how heart is formed and of how congenital heart diseases (CHD) are taken place. As it known, mistakes in spatiotemporal expression of critical genes result in congenital cardiovascular diseases. Furthermore, studies on high risk population of cardiovascular disease have also suggested the relationship between noncongenital cardiovascular diseases and genetic factors.Here we report the identification and characterization of a novel human gene, hLBH, from a human embryonic heart cDNA...