Effects Of Malondialdehyde On Growth And Proliferation Of Human Bone Marrow Mesenchymal Stem Cells In Vitro

According to carbonyl stress theory of aging, carbonyl-amine reaction as a common reaction of free radical oxidation and non-enzymatic glycosylation is an inevitable and irreversible core process during the slow aging procedure caused by oxidation and glycosylation. Because metabolic disturbance causes oxidative stress, reactive carbonyl compounds increase largely in bio-system and at last carbonyl stress appears. AGEs and ALEs can be generated and accumulated because of carbonyl stress. Reactive carbonyl compounds not only have a direct physiological effect on cells but also cause a series of pathological damage through promoting the accumulation of AGEs or ALEs.Mesenchymal stem cell is a kind of adult stem cell, the multi-potential of these cells, their easy isolation and culture, as well as their high ex vivo proliferation potential make these cells an attractive therapeutic tool. Cumulative data have been documented that mesenchymal stem cells can differentiate into osteoblasts, chondrocytes, adipocytes, tenocytes, myotubes, neural-like cells, hematopoietic-supporting stroma and other non-hematopoietic cells derived from mesoblast or ectoblast. MSCs participate in tissue renewing and damage repair. During ageing process, the numbers of MSCs decrease and their...