Effects Of Lovastatin And Monascus Ruber On Growth Inhibition And Induced Apoptosis Of D6 Cells

Lovastatin, the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, is generally applied in the treatment of hypercholesterolemia. It is recently demonstrated that lovastatin inhibits proliferation of tumor cells and triges apoptosis.hi the precent study, the effect of lovastatin on human lung cancer D6 cell was examined and the role of cholesterol involving in the process of growth-inhibition and induced apoptosis of cell treated with lovastatin was investigated. Also, the anti-tumor function of lovastatin hi vivo was assessed utilizing Monascus mber containing lovastatin.It was showed that lovastatin effectively inhibit proliferation of D6 cell, and its ICso value is approximate 150umol/L. Treatment withlOumol/L lovastatin for 24 hour anests cells in the Go/Gi and to 72 hour, induced obivious apoptosis. Adding exogenous cholesterol can partly invert the lovastatin-mediated growth-inhibition and induced apoptosis, indicating that cholesterol maybe involved in the regulation mechanism of lovastatin. The anti-tumor effect of Monascus mber containing lovastatin in vivo was not significant hi the SI80 tumor modle. Finally, the mechanisms of growth-inhibition and induced apoptosis with lovastatin were disccused on the basis of the results obtained hi the present study.