Polarization-Sensitive Optical Coherence Tomography With Different Functions And Their Applications

Optical Coherence Tomography(OCT)has been widely used in clinical diagnosis and scientific research to provide high-resolution images of tissues.But,it can only provide intensity information.Polarization Sensitive Optical Coherence Tomography(PS-OCT),a functional imaging technology derived from OCT,is not only capable of structurally imaging biological tissues but also quantitatively evaluate the polarization properties of tissue samples,such as birefringence.Therefore,PS-OCT technology has been widely used in both medical and non-medical fields due to these advantages.However,there are also shortcomings for measuring the polarization characteristics of tissue samples using PSOCT,because the randomly initial phase results in the inaccurate birefringence of the sample information,and the measurement only considered the linear birefringence properties,ignoring the circular birefringence properties.Mueller matrix can completely describe the polarization characteristics of scattering media.However,to measure a complete Mueller matrix to characterize the polarization characteristics of samples,it takes a lot of time to complete data collection,and the imaging speed needs to be further improved.Moreover,the specific properties and applications of the 16 elements in the Mueller matrix are less studied.In this dissertation,several PS-OCT systems with different functions are proposed based on the Mueller matrix and Jones matrix,and their applications in biological tissues are explored,and a series of achievements have been achieved.The innovations of this dissertation mainly include the following aspects:1.An Orthogonal Polarization gating Optical Coherence Tomography(OPG-OCT)system has been developed to recognize the helical structure of human sweat glands.This technology can be applied to fingerprint information encryption to improve its security.2.The ellipsoid and ellipse methods were used to quantitatively analyze the threedimensional sweat ducts and pores of different depths.The ellipsoid method can be used to quantitatively describe the length and diameter of sweat ducts.the method can be used to estimate the resonance frequency of electromagnetic wave interaction with human skin.In addition,sweat holes and projection-based internal fingerprints are superimposed on each other to create a hybrid internal fingerprint that can be used for biometrics and information encryption.3.A polarization coherent matrix tomography system was proposed based on coherent matrix combined with Mueller matrix,eliminating the influence of the randomly initial phase of polarized light and characterizing the polarization properties of the samples.The system can quantitative the myocardial tissue and provide potential application for myocardial diseases in medical diagnosis.