| Objective:Rheumatoid Arthritis(RA)is a widespread and chronic autoimmune disease with a high disability rate leading to a serious negative impact on a patient's quality of life.In accordance to evidence-based medicine,this research uses Meta-analysis method to systematically analyze the results of TCM treatment on various RA syndromes,compare the efficacy of TCM treatment on various RA syndromes,and provide objective data for more standardized and effective application of traditional Chinese medicine in the treatment of RA.Method:Usage of the computer to search for relevant RCT literature from CNKI since the establishment of the database on October 31,2018.The search content is based on the 8 major Chinese medicine syndromes of Rheumatoid Arthritis in the "Guidelines for Combined Diagnosis and Treatment of Rheumatoid Arthritis".The 8 syndromes are Rheumatism stasis syndrome,Cold dampness syndrome,Hot dampness syndrome,Phlegm and Blood stasis syndrome,Blood stasis syndrome,Qi and Blood deficiency syndrome,Liver and Kidney deficiency syndrome,Qi and Yin deficiency syndrome.Meta-analyze the relevant data extracted from the articles that meet the standards for each syndrome by their heterogeneity,effect value combination and funnel chart analysis of the efficacy indicators;compare the differences in the efficacy of traditional Chinese medicine(including Chinese&Western medicine combination)versus Western medicine in the treatment of RA.In the subgroup analysis,compare the differences between the treatment efficacies of pure Chinese medicine versus Western medicine,and Chinese&Western medicine combination versus Western medicine in the treatment of RA.Finally,compare the efficacy of Chinese medicine versus Chinese&Western medicine combination on the 8 RA syndromes.Results:This study incorporates 188 standard RCT literature,with a total sample size of 16615 cases:8680 cases in the Chinese medicine(including Chinese&Western medicine combination)group,7935 cases in the Western medicine group.2 Subgroups:4416 cases in the pure Chinese medicine subgroup versus 3778 cases in the related Western medicine subgroup and 4264 cases in the Chinese&Western medicine combination subgroup versus 4157 cases in the related Western medicine subgroup.(1)Rheumatism stasis syndrome:12 RCT literature with 1207 cases.The treatment efficiency of the Chinese medicine(including Chinese&Western medicine combination)group and the Western medicine group were 92.24%and 77,26%,respectively[OR(95%CI)=3.62(2.54,5.17),P<0.00001].Subgroup 1 analysis of pure Chinese medicine group-versus Western medicine:8 RCT literature with 1006 cases.The effective rates of treatment in the pure Chinese medicine and the Western medicine category were 92.63%and 78.19%,respectively[RR(95%CI)=1.19(1.31,1,25),P<0.00001].Subgroup 2 analysis of Chinese&Western medicine combination versus Western medicine:4 RCT literature with 201 cases.The Chinese&Western medicine combination subgroup's and Western medicine subgroup's treatment efficiencies were 90.10%and 73.00%respectively[RR(95%CI)=1.23(1.08,1.41),P=0.002].(2)Cold dampness syndrome:66 RCT literature with 5617 cases.The treatment efficiencies of the Chinese medicine(including Chinese&Western medicine combination)group and the Western medicine group were 90.83%and 76.43%respectively[OR(95%CI)=3.08(2,64,3.61),P<0.00001].Subgroup 1 analysis of pure Chinese medicine versus Western medicine:24 RCT literature with 3301 cases.The treatment efficiencies of the pure Chinese medicine subgroup and the Western medicine subgroup were 92.61%and 78.23%respectively[RR(95%CI)=1.18(1.11,1.25),P<0.00001].Subgroup 2 analysis of Chinese&Western medicine combination versus Western medicine:42 RCT literature with 201 cases.The effective rates of treatment in the Chinese&Western medicine combination subgroup and the Western medicine subgroup were 89.50%and 75.26%respectively[RR(95%CI)=1.16(1.13,1.20),P<0.00001].(3)Hot dampness syndrome:42 RCT literature with 3570 cases.The treatment efficiencies of the Chinese medicine(including Chinese&Western medicine combination)group and the Western medicine group were 90.14%and 73.50%respectively[OR(95%CI)=3.45(2.85,4.18),P<0.00001].Subgroup 1 analysis of pure Chinese medicine subgroup versus Western medicine subgroup:28 RCT literature with 2441 cases.The effective rates of treatment in the pure Chinese medicine group and the Western medicine group were 90.65%and 75.67%respectively[RR(95%CI)=1.17(1.12,1.23),P<0.00001],Subgroup 2 analysis of Chinese&Western medicine combination versus Western medicine:14 RCT literature with 1129 cases.The Chinese&Western medicine combination subgroup's and Western medicine subgroup's treatment eficiencies were 88.99%and 69.12%respectively[RR(95%CI)=1.26(1.19,1.33),P<0.00001].(4)Phlegm and Blood stasis syndrome:22 RCT literature with 1817 cases.The effective rates of treatment in the Chinese medicine(including Chinese&Western medicine combination)and Western medicine groups were 91.75%and 73.77%respectively[OR(95%CI)=4.09(3.08,5.42),P<0.00001].Subgroup 1 analysis of pure Chinese medicine subgroup versus Western medicine subgroup:5 RCT literature with 300 cases.The effective rates of treatment in the pure Chinese medicine subgroup and the Western medicine subgroup were 92.81%and 76.87%respectively[RR(95%CI)=1.18(1.04,1.34),P=0.01].Subgroup 2 analysis of Chinese&Western medicine combination versus Western medicine:17 RCT literature with 1517 cases.The Chinese&Western medicine combination subgroup's and Western medicine subgroup's treatment efficiencies were 91.54%and 73.16%respectively[RR(95%CI)=1.21(1.14,1.29),P<0.00001].(5)Blood stasis syndrome:17 RCT literature with 1612 samples.The effective rates of treatment in the Chinese medicine(including Chinese&Western medicine combination)group and the Western medicine group were 91.83%and 74.75%respectively[OR(95%CI)=3.77(2.80,5.08),P<0.00001].Subgroup 1 analysis of pure Chinese medicine subgroup and Western medicine subgroup:5 RCT literature with 394 cases.The effective rates of treatment in the pure Chinese medicine subgroup and the Western medicine subgroup were 94.20%and 81.28%respectively[RR(95%CI)=1.14(1.03,1.27),P=0.01],Subgroup 2 analysis of Chinese&Western medicine combination versus Western medicine:12 RCT literature with 1218 cases.The effective rates of the Chinese&Western medicine combination subgroup and the Western medicine subgroup were 91.03%and 72.73%respectively[RR(95%CI)=1.23(1.16,1.31),P<0.00001].(6)Qi and Blood deficiency syndrome:9 RCT literature with 904 cases.The treatment efficiencies of the Chinese medicine(including Chinese&Western medicine combination)group and the Western medicine group were 91.43%and 75.06%respectively[OR(95%CI)=3.56(2.41,5.28),P<0.00001].Subgroup 1 analysis of pure Chinese medicine subgroup and Western medicine subgroup:2 RCT literature with 168 cases.The effective rates of treatment in the pure Chinese medicine subgroup and the western medicine subgroup were 93.10%and 77.78%respectively[RR(95%CI)=1.20(1.05,1.37),P=0.006].Subgroup 2 analysis of Chinese&Western medicine combination subgroup and Western medicine subgroup:7 RCT literature with 736 cases.The Chinese&Western medicine combination subgroup and Western medicine subgroup treatment efficiency were 91.03%and 74.46%respectively[RR(95%CI)=1.22(1.14,1.31),P<0.00001].(7)Liver and Kidney deficiency syndrome:20 RCT literature with 1888 cases.The effective rates of treatment in the Chinese medicine(including Chinese&Western medicine combination)and Western medicine groups were 87.91%and 69.97%respectively[OR(95%CI)=3.32(2.59,4.26),P<0.00001].Subgroup 1 analysis of pure Chinese medicine subgroup and Western medicine subgroup:16 RCT literature with 1575 cases.The effective rates of treatment in the pure Chinese medicine subgroup and the Western medicine subgroup were 89,33%and 71.33%respectively[RR(95%CI)=1.26(1.19,1.32),P<0.00001].Subgroup 2 analysis of Chinese&Western medicine combination treatment subgroup and Western medicine subgroup:4 RCT literature with 313 cases.The Chinese&Western medicine combination subgroup's and Western medicine subgroup's treatment efficiencies were 80.13%and 63.69%respectively[RR(95%CI)=1.25(1.10,1.43),P=0.0010].(A P value of less than 0.05 indicates that the comparison of the treatment efficacies is statistically significant.)(8)Qi and Yin deficiency syndrome:0 RCT literature.As relevant articles that meet the standard cannot be retrieved,Meta-analysis cannot be performed and there is no data to participate in the comparison of efficacies between treatments.Conclusion:Meta-analysis results show that the total effective rate of each RA syndrome in the Chinese&Western medicine combined treatment and pure Chinese medicine subgroup is better than that of Western medicine treatment group;dampness and heat syndrome and blood stasis syndrome is better than pure traditional medicine group on treatment effect. 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