Effects Of Chromogranin A-Derived Peptides And Tetranectin On Cardiovascular System

Background—Coronary artery disease is a chronic inflammatory-fibroproliferative arterial disease.The imbalance between coagulation and fibrinolytic system and chronic persistence inflammation play two major role in the development of atherosclerosis.Previous studies have demonstrated that a range of inflammatory conditions is associated with pathologically high levels of circulating chromogranin A and tetranectin is a key regulator of fibrinolysis and proteolytic system.We thus investigated the association among chromogranin A-derived peptides(catestatin and pancreastatin),tetranectin and coronary artery disease and take further exploration of the underlying mechanism.Methods and Results—We conducted a systematic serologic analysis,in vitro cellular experiments and in vivo animal research to confirm our assumption and the key findings of the current study are(1)Serum catestatin concentration was negatively associated with the severity and progression of atherosclerosis and catestatin plays an anti-inflammatory role in the development of atherosclerosis.This signaling pathway might be partially mediated by angiotensin converting enzyme 2(ACE2);(2)Pancreastatin was an independent factor associated with the presence of acute myocardial infarction and pancreastatin level was an independent prognostic factor that affected post-infarction cardiac dysfunction;(3)Increased serum TN level is associated with the presence and severity of diseased coronary arteries in patients with stable CAD.Conclusions—In conclusion,our study identify for the first time that(1)Serum catestatin levels could act as a crucial factor in evaluaing the severity of CAD and ACE2 might be the key mediator to modulate the anti-atherosclerotic effect of catestatin;(2)An elevated serum pancreastatin level in patients with acute myocardial infarction,and PST level at admission could predict the incidence of heart failure in patients after acute myocardial infarction;(3)Tetranectin levels in serum are associated with the presence of CAD and number of diseased vessels in patients with stable CAD.