| Despite the huge investment of Saudi government in improving the quality of health care system and infrastructure, the adoption rate of information technologies and Computerized Physician Order Entry system (CPOE) in Saudi Arabia is limited. This qualitative phenomenological study explored the pharmacists' perceptions and satisfaction level with the use of CPOE systems in Riyadh, the capital of Saudi Arabia. The results of this study provided rich descriptions of the determinants affecting the pharmacists' satisfaction with CPOE systems, including CPOE features, its effect on quality and safety, perceived usefulness, training, and effect on efficiency of pharmacists. The key recommendation is considering and addressing such determinants will support the decision makers in achieving higher satisfaction rate among pharmacists in Saudi Arabia and assuring a high rate of adoption of CPOE systems. |