Given a self-diffeomorphism ϕ of a closed, orientable surface S with genus greater than one and an embedding f of S into a three-manifold M, we construct a mutant manifold by cutting M along f( S) and regluing by fϕf-1. We will consider whether there exist nontrivial gluings such that for any embedding, the manifold M and its mutant have isomorphic Heegaard Floer homology. In particular, we will demonstrate that if ϕ is not isotopic to the identity map, then there exists an embedding of S into a three-manifold M such that the rank of the non-torsion summands of HF&d14; of M differs from that of its mutant. We will also show that if the gluing map is isotopic to neither the identity nor the genus-two hyperelliptic involution, then there exists an embedding of S into a three-manifold M such that the total rank of HF&d14; of M differs from that of its mutant. |