Immune complex - macrophage interactions and the pathogenesis of arteriosclerosis

he purpose of this research is to study the effect of HMM activation by immune complexes on n-LDL metabolism.;In conclusion, we have obtained experimental evidence demonstrating that incubation of HMM with LDL-IC leads to cell CE accumulation, inducing the transformation of these cells into foam cells and that when the LDL-IC are taken up by the Fc receptor there is a marked enhancement of LDL receptor expression. (Abstract shortened with permission of author.).;In order to determine if the uptake of LDL-IC or the increased expression of LDL receptors or both were responsible for the transformation of HMM into foam cells, we activated the HMM for 22h with LDL-IC (250...