The role of low-density lipoprotein immune complexes in the transformation of macrophages into foam cells |
Posted on:1994-01-01 | Degree:Ph.D | Type:Dissertation |
University:Medical University of South Carolina | Candidate:Shunk, Kendrick Alan | Full Text:PDF |
GTID:1474390014494629 | Subject:Cellular biology |
Abstract/Summary: | |
acrophages are transformed into foam cells upon exposure to LDL immune complexes (LDL-IC). The clinical relevance of this is supported by a correlation between anti-LDL titers and progression of carotid atherosclerosis. Previous studies demonstrated a marked accumulation of cholesteryl esters in human monocyte-derived macrophages (HMM) incubated with LDL-IC. Here we investigated macrophage metabolism of LDL-IC and their cholesterol homeostatic response to LDL-IC. Using... |
Keywords/Search Tags: | LDL-IC |
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