THE USE OF OXYGEN CHIRAL PHOSPHODIESTERS IN STEREOCHEMICAL STUDIES OF ENZYMATIC NUCLEOTIDYL TRANSFER REACTION

Posted on:1982-11-06

Degree:Ph.D

Type:Dissertation

University:Yale University

Candidate:CODERRE, JEFFREY ALBERT

Full Text:PDF

GTID:1471390017465866

Subject:Biochemistry

Abstract/Summary:

The stereochemical course of the reaction catalyzed by the adenylate cyclase from Brevibacterium liquefaciens was investigated using the phosphorothioate substrate analog adenosine 5'-(0-1-thiotriphosphate) (ATP(alpha)S). The diastereomer of ATP(alpha)S having the S(,p) configuration at the (a.

Keywords/Search Tags:

Stereochemical

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