| Cytochromes P-450 are a superfamily of monooxygenases which metabolize a myriad of endogenous and exogenous substances. Cytochrome P-450 genes are differentially expressed in various tissues and differentially induced by many chemical agents. The rabbit cytochrome P-450IIC subfamily contains both phenobarbital inducible and constitutive genes. Comparative studies of the gene structures of this subfamily may shed light on the mechanism of differential induction of cytochrome P-450 genes. The purpose of this project is to characterize the cytochrome P-450IIC3 gene, which is a constitutive gene with respect to phenobarbital, and the 5... |
