Design and synthesis of protein-tyrosine kinase inhibitors
Posted on:1998-10-31
Degree:Ph.D
Type:Dissertation
University:State University of New York at Buffalo
Candidate:Lai, Jack Hungsen
Full Text:PDF
GTID:1464390014976195
Subject:Biology
Abstract/Summary:
The association of tyrosine phosphorylation with both oncogenesis and growth factor-dependent mitogenesis has suggested an important role for protein tyrosine kinases (PTK) and their substrates in the control of cell proliferation. Our research group has identified the best pentapeptide substrate known so far for the pp60;A variety of short peptide derivatives were synthesized as potential protein kinase inhibitors with the general structure Ac-Ile-AA-Gly-Glu-Phe-NH...