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The role of the carboxy terminus of tropoelastin in extracellular elastin assembly

Posted on:1999-07-03Degree:Ph.DType:Dissertation
University:Boston UniversityCandidate:Hsiao, HsiungFull Text:PDF
GTID:1464390014971532Subject:Biochemistry
Abstract/Summary:
Tropoelastin, the soluble precursor protein of insoluble elastin, contains repeating units that function in providing both elasticity as well as cross-linking sites. Tropoelastin also contains a unique carboxy terminal domain encoded by exon 36 that may play a role in the process of insolubilization. Using expression vectors that encoded full length tropoelastin or tropoelastin devoid of the region encoded by exon 36, (...
Keywords/Search Tags:Tropoelastin
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