| n the murine model of Schistosoma japonicum infection, immunization with irradiated cercariae or freeze/thawed schistosomula induces partial protection against cercarial challenge. This protective activity can be transferred to naive mice with the immunoglobulin fraction of immune sera. The objective of the following study was to identify parasite immunogens responsible for generating this protective antibody response. We produced an anti-schistosome monoclonal antibody (Mab A6, IgM isotype). In passive transfer experiments, Mab A6 reduced worm burdens in mice following cercarial challenge by up to 47% (p... |
