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Pyridoxamine-cyclodextrin conjugates as transaminase mimics

Posted on:1998-04-13Degree:Ph.DType:Dissertation
University:Columbia UniversityCandidate:Fasella, ElisabettaFull Text:PDF
GTID:1464390014479397Subject:Chemistry
Abstract/Summary:
With the goal of obtaining enantioselective transaminase mimics, several synthetic schemes have been devised for doubly linking a pyridoxamine moiety through thioether linkages from the 2;The substrate selectivities of ;A number of cyclodextrin derivatives doubly functionalized with a pyridoxamine and a base have been synthesized and the stereoisomers separated. These transaminase mimics have been tested for optical induction in transamination reactions of...
Keywords/Search Tags:Transaminase mimics
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