Design and synthesis of novel scaffolds for drug discovery: Hybrids of beta-D-glucose with 1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one and the corresponding 1-oxazepine, and 2- and 4-pyridyldiazepines

We describe the syntheses of novel tricyclic scaffolds which incorporate a fusion of a substituted pyranose ring with the seven membered rings of 1,2,3,4-tetrahydrobenzo[ e][1,4]diazepin-5-one and the corresponding oxazepine and pyridyldiazepine to generate the benzodiazepines, and the related heterocycles. In each instance, the pyranose rings contain three protected hydroxyls, suitable for selective derivatization.*; *Please refer to dissertation for diagram.