| The first goal of this project was to test the feasibility of a new chromatographic separation technique, Micellar Electrokinetic Capillary Chromatography (MECC), in estimating the octanol-water partition coefficient ;The second goal of this project was to examine the effects of MECC buffer composition towards ;Additionally, the effects of a small amount of organic on hydrophobicity estimation was tested. A small amount of organic has been shown to be quite useful for separating extremely hydrophobic compounds in MECC. Perhaps the ;The third goal of this project is at a bit of a tangent to the first two. Many diverse biological actions are estimated by ;As an alternative, micelles possess chain densities on the order of lipid bilayers, representing a much better biomimetic compared to bulk octanol from a thermodynamic standpoint. MECC capacity factors were evaluated as a predictor of bioconcentration and other diverse physiological actions, instead of... |
