Fas ligand gene regulation by NF-(kappa)B

CD95 (Fas) ligand is a type II transmembrane protein that belongs to the tumor necrosis factor superfamily. Upon binding to its receptor, Fas, Fas ligand delivers a signal that leads to apoptosis of Fas-expressing cells. The ability of Fas ligand to induce lymphocyte cell death plays a critical role in the containment of autoimmunity and in the maintenance of lymphocyte homeostasis. Therefore, the goal of this project was to investigate what transcription factor(s) is responsible for the regulation of Fas ligand gene expression.;The effect of the proteasome inhibitors, lactacystin and LLnL, was investigated on the nuclear translocation of the transcription factors AP-1, NFAT;In order to investigate whether these NF-...