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Signals in DNA that affect nucleosome alignment and gene regulation

Posted on:1997-10-23Degree:Ph.DType:Dissertation
University:Purdue UniversityCandidate:Liu, KeyiFull Text:PDF
GTID:1460390014982194Subject:Molecular biology
Abstract/Summary:
ukaryotic DNA is packaged into chromatin which contains periodic arrays of nucleosomes. The nucleosome arrays reflect or influence the higher-order chromatin structure and function. Despite their importance in the higher-order chromatin structure and gene regulation, it is unclear how nucleosome arrays are formed.;Using an in vitro chromatin assembly system, we first investigated how a shortened nucleosome repeat arises specifically on...
Keywords/Search Tags:Nucleosome, Chromatin, Arrays
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