Formal Analysis of Automated Model Abstractions under Uncertainty: Applications in Systems Biology |
Posted on:2013-09-07 | Degree:Ph.D | Type:Dissertation |
University:University of Cincinnati | Candidate:Ghosh, Krishnendu | Full Text:PDF |
GTID:1458390008478581 | Subject:Biology |
Abstract/Summary: | |
In this dissertation, three fundamental problems in modeling of large scale biological systems are addressed.;1. Modeling of chemical reaction under imprecise rate of reactions: A framework is created to model chemical reactions with an interval based approach, incorporating imprecision as well as creating a finite space. Algorithms are presented to construct model abstraction efficiently. The results of the algorithms on a prototype elucidate the model. The formalism presents a novel way to represent continuous data of concentrations for the chemicals and quantitative analysis of temporal behavior of the system.;2. Multiscale formalism in discrete domains: Biological processes are multiscale. We formalize the definition of multiscale modeling in discrete domains. A polynomial algorithm is constructed to compute identifiability of multiscale systems.;3. Formal analysis of gene regulatory network: A formalism that incorporates noise in the data is presented to study gene regulation. Computational efficiency of the formalism is evaluated on a prototype constructed from biological experimental data. |
Keywords/Search Tags: | Model, Systems, Biological, Formalism |
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