| The human genome contains numerous regulatory elements that have evolved to control gene expression. To better understand gene regulation in the human cell, we analyzed genome-wide profiles of gene expression and protein-DNA interactions. We concluded that (1) the concentration of regulated molecules (mRNAs) can differentially affect the activity of the regulator molecules (microRNAs); (2) cell-type specific chromatin binding proteins depend on both cofactor proteins and chromatin accessibility; and (3) Epstein-Barr virus pervasively interacts with the human genome. Our results enable us to better understand development of distinct cell types, design criteria of small RNA therapeutics, and the role of host factors in virus-induced malignancies. |
