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The male osteoporosis: Pathogenesis and therapy (Hungarian text)

Posted on:2006-01-20Degree:Ph.DType:Dissertation
University:Semmelweis Egyetem (Hungary)Candidate:Toth, Edit AgnesFull Text:PDF
GTID:1454390008474669Subject:Health Sciences
Abstract/Summary:
The objective of this study was to examine the appearance of osteoporosis in men. My new establishments to conclude the results are as follows: (1) There is a little population-based data concerning Hungarian prevalence rate of male osteoporosis. According to our results and international observations the incidence of male osteoporosis must be higher than we thought earlier. (2) Chronic back pain is frequently caused by osteoporosis in men. (3) Excessive alcohol consumption highly contributes to bone loss among Hungarian men. (4) Beside the older age the low body weight are considered to be risk factors for bone loss in men. (5) We do not have exact data about the prevalence of idiopathic and secondary osteoporosis in men, but idiopathic male osteoporosis seems to be more common among middle-aged men in our study. (6) Between the secondary causes of osteoporosis the alcohol-induced male osteoporosis might be more frequent in Hungary. (7) Total testosterone and estrogen levels are not correlated to the decrease of BMD at any skeletal sites. (8) The age related decrease in adrenal androgens may contributes to the involutional bone loss in men. (9) The decrease of serum 25-hydroxycholecalciferol is also very common among men. (10) Over age 65 in men, vitamin D deficiency induces secondary hyperparathyroidism, which causes bone loss. (11) Bone fracture is a common symptom of osteoporosis in men. It is more frequent in secondary osteoporosis, however more serious fractures develop in idiopathic osteoporosis. (12) The modified Minne method is an accurate and sensitive method, which can also be used to estimate vertebral deformities in men. (13) Vertebral deformities are very common cause of idiopathic osteoporosis, that can be established by an objective method. (14) Beside bone mass, so-called "non-mass" properties have role on development of vertebral deformities. (15) The SOS, which is one of the QUS parameters, gives further BMD-independent information on bone and that is able to predict the risk of vertebral fractures in men. (16) Calcitonin treatment induces bone mineral acquisition in men with idiopathic osteoporosis. (17) The risk of having further vertebral fractures can be reduced by 30% on calcitonin treatment in idiopathic osteoporosis. (18) Active vitamin D treatment can be used as an alternative of atiresorptive therapy in idiopathic male osteoporosis, especially in relative vitamin D deficiency.
Keywords/Search Tags:Osteoporosis, Men, Idiopathic, Hungarian, Bone loss
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