| Blood-brain barrier disruption in Parkinson's disease and Parkinson's disease models that involve dopaminergic neurodegeneration has been minimally evaluated despite mounting evidence for its involvement. Oxidative stress and neuroinflammation are both involved in Parkinson's disease pathology and also both contribute to blood-brain barrier dysfunction, creating the likelihood that blood-brain barrier disruption is also a pathological feature of the disease. Disruption of the blood-brain barrier can lead to an increased susceptibility to neuronal injury and potentially neurodegeneration due to the invasion of peripheral factors such as immunoglobulins and environmental toxins into the brain. An understanding of mechanisms by which blood-brain barrier disruption occurs may lead to the development of new approaches for the treatment of neurologic diseases such as Parkinson's disease. |
