Study On Preparation,Bioactivity And Antibacterial Of New Orthopedic Magnesium Alloy(MG-1.5SN-XZN)

In recent years,the frequent occurrence of bone trauma has led to increasing demand for the development of magnesium alloy degradable orthopedic implant materials.Because of the problems that orthopedic implant surgery is often affected by infections and frequent inflammations,people have to incorporate the new biomaterial's design scope for the better biological activity,degradable characteristics,and certain antibacterial properties of the orthopedic implant materials.To solve these problems,we have designed a magnesium-based zinc-containing tin-tin alloy containing many biological activities.The magnesium-based alloy inherits the excellent characteristics of magnesium,including magnesium as an essential element in the human body,which is completely non-toxic and harmless to the human body;it has the characteristics of lightweight,compressive yield strength and elastic modulus closer to cortical bone,which can provide The mechanical support also reduces the stress shielding after bone implantation.However,due to the rapid degradation rate of magnesium metal,as an orthopedic internalfixation material,it is difficult to maintain its mechanical strength for a long enough time;we introduced a high solid solubility zinc element and tin element to the alloy,making the mechanics of the new magnesium-based alloy The performance is further improved.The elements of zinc and tin can optimize the alloy composition.Compared with magnesium,it can avoid the strong galvanic corrosion effect,thereby greatly reducing the degradation rate of the alloy.This paper is based on the early stage of the cooperation team research on Mg-xSn(x: 1,1.5,2,3),and selected the Mg-1.5Sn material with the lowest degradation rate as the basis,by adding Zn element(1%-4%)To further improve the performance of magnesium alloys.This paper designs and develops an antibacterial biodegradable Mg-Zn-Sn orthopedic implant material with biological activity.The introduction of high solid solubility Zn and Sn elements for alloying to improve the mechanical properties of magnesium;over-composition optimization to avoid strong galvanic corrosion effects,thereby greatly reducing the rate of magnesium degradation;after the development of Zn,Sn element alloying The biological functions such as promoting bone activity and antibacterial properties enable it to simultaneously promote the growth of new bone during the degradation process,exert antibacterial function to prevent infection,and enable the rapid healing and repair ofdamaged bone tissue.The synthetic Mg-1.5Sn-xZn alloy material was studied in PBS for its degradation characteristics.Based on in vitro screening,the material was further studied,in vitro safety experiment.biological activity,in vivo biosafety,anti-inflammatory and antibacterial experiment..Then make a screw-like piece that can be used clinically and implant it into the animal to simulate the performance of its clinical application.The successful research of this alloy is expected to solve the problems of a long healing period,secondary surgery,and frequent inflammation faced by clinical orthopedic implant materials.