Clinical Features And Prognosis Factors Of Surgically Resected Peripheral Small Cell Lung Cancer:An Analysis Of 82 Cases

Background and Objectives : Small cell lung cancer is one type of lung cancer characterized by a high degree of malignancy,which leads to its poor prognosis.Small cell lung cancer is more common in central and has a good respond to chemotherapy and radiotherapy,but relapses quickly.The pathogenesis of small cell lung cancer is still in progress.Studies have tried to explain the occurrence with cancer stem cell model of small cell lung cancer,which could explain the predilection of central and expression of neuroendocrine markers.This study observed the clinical characteristics and prognostic factors of peripheral small cell lung cancer.Methods: 82 cases surgically resected peripheral small cell lung cancer were collected from January 2008 to December 2012,which were first diagnosed and treated in Shanghai Chest Hospital,Shanghai Jiaotong University.Medical records were collected using queries in the system and telephone.Data was analyzed and processed by SPSS22.0.Data was analyzed and processed by SPSS 22.0.Kaplan-Meier was used to analyze PFS and OS and to plot the survival curve,Log-rank method was used to testify the significance.Cox proportional hazards model was used to identify the independent prognosis factor.P <0.05 was considered statistically significant.Results:The study included 82 patients,univariate analysis showed that age,gender,smoking index,pathological type,tumor location,surgical pattern,treatment pattern,prophylactic cranial irradiation were not the prognostic factors for PFS of surgically resected peripheral small cell lung cancer(P = 0.623,P = 0.767,P = 0.770,P = 1.560,P= 0.907,P = 0.715,P = 0.409,P = 0.212,> 0.05).Tumor size,T stage,N stage and stage were the main factors affecting surgically resected peripheral small cell lung cancer disease progression(P = 0.040,P = 0.036,P = 0.001,P = 0.003),multivariate analysis showed that T stage,N stage were the independent prognostic factors for PFS of surgically resected peripheral small cell lung cancer(RR 1.945;95% CI 1.008-3.742;P = 0.047;RR1.904;95% CI 1.298-2.791;P = 0.002).Age,gender,smoking index,pathological type,tumor location,surgical procedure,tumor size,T stage,treatment pattern,prophylactic cranial irradiation were not the prognostic factors for OS of surgically resected peripheral small cell lung cancer(P = 0.449,P = 0.889,P = 0.738,P = 0.113,P = 0.949,P= 0.841,P = 0.348,P = 0.096,P = 0.411,P = 0.106,> 0.05).N stage and overall stage were the main factors affecting surgically resected peripheral small cell lung cancer disease progression(P = 0.002,P = 0.01).Multivariate analysis showed N stage was the independent prognostic factors for OS of surgically resected peripheral small cell lung cancer(RR 1.883;95% CI 1.227-2.889;P = 0.004).Conclusions : 1.Age,gender,smoking index,pathological type,tumor location,surgical procedure,treatment pattern,prophylactic cranial irradiation were not the prognostic factors for PFS of surgically resected peripheral small cell lung cancer.2.Tumor size,T stage,N stage were the main factors affecting surgically resected peripheral small cell lung cancer disease progression,and the T stage,N stage were independent prognostic factors: higher T stage,N stage leads to shorter PFS.3.Age,gender,smoking index,pathological type,tumor location,surgical procedure,tumor size,T stage,treatment pattern,prophylactic cranial irradiation were not the prognostic factors for OS of the surgically resected peripheral small cell lung cancer.4.N stage and phase were majorfactors for OS of the surgically resected peripheral small cell lung cancer,and N stage was independent prognostic factor: higher N stage resulted in the shorter survival time.