Associations Between Chilhood Asthma And Typical POPs Exposures

Research purposes:Investigate the associations between asthma development in children aged 3-6years and internal/environmental exposures of typical POPs.Assess the potential health risks by exposures to typical POPs of children in indoor environment.We aim to afford refference for improvement of indoor environment and control of childhood asthma.Research contents:Asthmatic and non-asthmatic children aged 3-6 years in Shanghai urban were recruited,serum and indoor environmental samples(dust and PM_2.5)were collected for typical POPs measurement.Associations between childhood asthma and typical POPs exposure were assessed.Average daily doses of typical POPs exposure in home were also evaluated as well as the potential noncarcinogenic health risks by the exposures.Research methods:1.Asthmatic?n=620?and non-asthmatic?n=218?children were recuited based on clinically diagnosis and serum samples were collected.Serums were merged for experimental requiments,by which 124 and 109 samples for the case and control groups were obtained,respectively.200?L of serum was extracted from each pooled sample for lipid content analysis.Internal levels and inter-group differences of typical POPs were determined,associations between asthma development and POPs exposure were analyzed using statistical method.2.60 families were selected based on random sampling and the parents'approval,where environmental(dust and PM_2.5)mediums were sampled.At the same time,questionnaires were completed by the parents to analyse the potential risk factors related to childhood asthma.External exposure levels were determined as well as the inter-group differences,associations between asthma development and POPs exposure were analyzed using statistical method.3.Include the environmental data into the human exposure models.Average daily doses of POPs exposure were assessed according to related parameters.Risks of non-carcinogenic effects by POPs exposure were evaluated.Results:1.A total 47 typical POPs were detected with various detection frequencies in serum samples,with the general distribution trend:OCPs>PCBs>PBDEs.Internal levels of 37 analytes were relatively higher in the case group.2.Occurrences of childhood asthma were positively associated to internal exposure of 25 POPs;Associations were significantly improved under co-exposure of selected POPs;Severe asthma was positively associated with internal exposure to BDE-209.3.Non-stick pan use,weak ventilation of kitchen,molds in wall and allergic history were observed as potential risk factors of childhood asthma.4.Environmental levels of selected POPs were higher in the case group;Asthma development was positively associated with p,p'-DDE exposure.5.The estimated average daily doses of selected POPs exposure were higher via dust ingestion compared with inhalation;Related hazard quotients were lower than 1.Conclusions:1.Typical POPs exist in children body and their indoor environment with significant levels,which maybe persistent health risks and worthy of attention.2.Internal and external exposure of selected POPs might be potential risk factors for childhood asthma;The interactions between co-exposure of POPs need to be clarified.3.Excess potential risk factors of childhood asthma were observed on family features,indoor environment and related disease history,etc.4.Apparent non-carcinogenic health risks were not found with indoor exposure of tyical POPs.