Study On The Pathological Mechanism Of The Nature And Reversibility Of The Pulmonary Vascular Lesions In Congenital Heart Disease-related Pulmonary Hypertension

PART 1:Potential Biomarkers and Targets in Reversibility of Pulmonary Arterial Hypertension Secondary to Congenital Heart Disease:An Explorative Study(Pulm Circ.2018 Apr-Jun;8(2):2045893218755987.)Background:Whether pulmonary arterial hypertension(PAH)is reversible in congenital heart disease(CHD)is important for operability of CHD.But now little is known about that.Our research was aimed at exploring novel biomarkers and targets in the reversibility of CHD-PAH.Method:CHD-PAH patients diagnosed right heart catheterization(RHC)were enrolled(n=14).Lung biopsy was performed during the repair surgery.All patients were followed up for one-year,then mPAP were evaluated by RHC to determine the diagnosis of reversible(mPAP...