Potential Relationship Between Alterations Of Cortical Connectivity And Clinical Manifestations Of Mid-Stage Sporadic Parkinson's Disease

Objective: Many clinical manifestations of sporadic Parkinson's disease(sPD)can't be completely explained by the lesion of simple typical extrapyramidal circuit between striatum and substantia nigra.Therefore,this study aimed to search the new pathological brain regions associated with the multiple and complex clinical manifestations of sPD.Method: Sixty five patients with the mid-stage sPD and 35 healthy controls were recruited from the Han population of Chinese Mainland.The cortical connectivity was assessed by the seed-based correlation analysis(SCA)using the vertex-based morphology of MRI,seven different clusters in the brain regions of significant cortical thickness thinning derived from the regression analysis using brain size as covariates between sPD and control was selected as seeds.Result:sPD showed that the shorten cortical connectivity mainly occurred in the Frontal Orbital,Opercular,Triangular,Precentral,Rectus,Supplementary-Motor,Temporal Pole,Angular,Heschl,Parietal,SupraMarginal,Postcentral,Precuneus,Occipital,Lingual,Cuneus,Rolandic-Opercular,Cingulum,ParaHippocampal,Calcarine,Olfactory,Insula,Paracentral-Lobule and Fusiform regions at the mid-stage of sPD,and the major was bilateral.Conclusion: These findings suggest that the extensive shorten of cortical connectivity is one of possible pathogenesis caused the multiple and complex clinical manifestations in sPD.