| Object:1.To observe the impact of long-term caffeine-sodium Benzoate intake on development of coronary heart disease in male and the severity of coronary lesions and clinical prognosis.2.To observe the effect of different doses of caffeine-sodium Benzoate intake on brachial artery endothelial function in male patients with coronary heart disease but without diabetes mellitus and the severity of coronary lesions and clinical prognosis.3.To observe the effect of different doses of caffeine-sodium Benzoate intake on biomarkers such as hyper-sensitivity C-reactive protein,adiponectin,homocysteine,serum uric acid,fibrinogen,and determine the correlation between these markers and the severity of coronary artery disease and endothelial function.Main Content:The first chapter:Impact of Long-term Caffeine-sodium Benzoate Intake on Development of Coronary Heart Disease in MaleMethod:1.A total of 2001 male caese undergoing selective coronary angiography were divided into caffeine-sodium Benzoate intake group(daily intaking caffeinum Natrio benzoicum ananka 1-6 times,274-1644mg/ days,more than 10 years)(n= 326)and non-intaking group((n= 1675).2.To compare the prevalence of coronary heart disease,age,risk factors,severity of coronary artery disease,MACE events between two groups.Results:1.The prevalence rate of coronary heart disease is significantly higher,in caffeine-sodium Benzoate group compared with non-intaking group(91.72% vs 86.09%,P<0.01),the age is significantly younger(52.14±10.1 vs 55.37±9.4,P<0.05.Accompany hypertension and diabetes is signifi-cantly lower,while accompany smoking cigarette significantly higher in the former group(P<0.01).2 When further divided into simple smoking group,simple caffeine-sodium Benzoate group and combined group,the prevalence rate of combined group is significantly higher than that of simple smoking group(93.11% vs 88.19%,P<0.05),3.The proportion of acute coronary syndromes,the incidence of MACE,and the proportion of bleeding in type 2 or over defined by BARC are not significantly different between three groups(P>0.05).4.The proportion of the anterior descending branches in the smoking group is significantly higher than that in the combined group(72.29%,vs,62.30%,P<0.01).The proportion of more than 70% stenosis in combined group is significantly higher than those of the simple smoking group(64.92% vs 54.29%,P<0.01).The second chapter:The Effect of Long-term Intaking of Caffeine-sodium Benzoate on Endothelial Function and Severity of Coronary Artery in Male CHD Patients.Method:1.90 cases of patients with CHD in our hospital were sequentially divided into 3 groups,30 cases of daily caffeine-sodium Benzoate intaking(274-822mg/day for more than 10 years)(group I),30 cases of daily consumption of caffeine-sodium Benzoate(823-1644mg/ day for more than 10 years)(group II),30 cases of daily smoking cigarette but no caffeine-sodium Benzoate(control group).All subjects were confirmed by selective coronary angiography for coronary heart disease and excluded from diabetes mellitus.2.Registration of three groups of patients with coronary heart disease risk factors and clinical classfication,cardiac function,coronary Gensini score,the incidence of MACE in all patients,determination of endothelial function of brachial artery by high-resolution ultrasound.Results:1.The age and risk factors of coronary heart disease have no significant difference among the three groups(P>0.05).2.The flow-mediated dilation(FMD)of three groups are lower than that of nitroglycerin-mediated dilation(NMD),but the difference was not significant(P>0.05).In group II,FMD decrease most but not reaching significance(P>0.05).3.FMD and severity of coronary lesions in three groups are not significantly different(P>0.05).Patients in group II have higher Gensini score compared with the other two groups but not reaching significance(P>0.05).There are no significant correlation between FMD and coronary Gensini scores(P>0.05).4.The proportion of acute coronary syndrome,the incidence of MACE have no significant difference among the three groups(P>0.05).The third chapter: Impact of Long-term Caffeine-sodium Benzoate Intake on Biomarkers in Male CHD Patients.Method:1.90 cases of patients with CHD in our hospital patients were sequentially divided into 3 groups,30 cases of daily caffeine-sodium Benzoate intaking(274-822mg/day for more than 10 years)(group I),30 cases of daily consumption of caffeine-sodium Benzoate(823-1644mg/ day for more than 10 years)(group II),30 cases of daily smoking cigarette but no caffeine-sodium Benzoate(control group).All subjects were confirmed by selective coronary angiography for coronary heart disease and excluded from diabetes mellitus.2.Biomarkers such as hyper-sensitivity C-reactive protein,adiponectin,homocysteine,serum uric acid,fibrinogen were measured and determined the correlation between these markers and severity of coronary artery disease and endothelial function.Results:1.The biomarkers among three groups are not significantly different(P>0.05).But there are increasing trends of hs-CRP,FIB,TC and LDL-c in group II compared with group I and the control group(P>0.05).2.In patients with AMI and ACS hs-CRP and coronary Gensini scores are positively correlated(r=0.441,r=0.384,P<0.01).TG is positively correlated with coronary Gensini score(r=0.515,P<0.01)in patients with UAP.,while HDL-c negatively correlated with coronary Gensini score(r=-0.435,P<0.05)in ones with UAP.TC and SUA were positively correlated with coronary Gensini score(r=0.25,r=0.267,P<0.05)in patients with ACS.There was no significant correlation between other biological markers and coronary Gensini scores(P>0.05).Conclusion:1.Male people with long-term caffeine-sodium benzoate intaking have higher incidence of coronary heart disease and more younger than controls.The prevalence rate of coronary heart disease and severity of coronary heart disease in combined intaking caffeine-sodium benzoate and cigarette are significantly higher than that of simple smoking group.2.Endothelial function and severity of coronary artery have no significant difference among different caffeine-sodium benzoate doses intaking groups and control group in patients with coronary heart disease but without diabetes mellitus.But high dose of affeine-sodium benzoate intaking have the trend of damaging endothelial function and increasing severity of coronary artery lesion.1.All biomarkers have no significant difference among different caffeine-sodium benzoate doses intaking groups and control group in patients with coronary heart disease but without diabetes mellitus.But in patients with ACS,hs-CRP,TG,TC and SUA are positively correlated with coronary Gensini scores while HDL-c negatively correlated with coronary Gensini score. |
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