The Application Of Radiofrequency Ablation Guided By MRI In The Treatment Of Breast Cancer

Objective To investigate the value of percutaneous radiofrequency ablation guided by MRI in the treatment of breast cancer.Methods Twelve cases of breast cancer patients diagnosed pathologically by biopsy,including 7 cases of clinical stage IV(6 cases with lung metastasis and 1 case with bone metastasis).And the other 5 cases of clinical stage III were diagnosed with severe hypertension,diabetes or kidney dysfunction,and their conditions were not fit for surgery because of contraindications or age.Before receiving the treatment of radiofrequency ablation,all the patients were treated with 4~6 cycles of chemotherapy,endocrine therapy or other systemic therapy,yet no further shrinking of residual breast lesions could be found.Furthermore,the imaging examination showed that breast lesions still remained,and another test of biopsy pathology confirmed the existence of active tumor tissue cells.Next,we performed radiofrequency ablation for breast lesions,followed by clinical and imaging follow-up 1,3,6 and12 months after the treatment.Results The twelve patients received a total of 18 times of radiofrequency ablation,all patients completed the treatment successfully.MRI examination showed necrosis of tumor lesions,disappearance of intratumoral blood supply,and no enhancement area was found.The ADC value before and after radiofrequency ablation increased from 0.855±0.046×10-3 to 1.26±0.148×10-3,which was a statistically significant difference(P<0.01).After 6 months to 1 years,the breast lesions were blurred or disappeared,and the effect of radiofrequency ablation was well.All patients achieved pathological complete remission(PCR),and the effective rate was 100%,postoperative follow-up of 6~16 months,all patients had no local recurrence or new distant metastasis.The average tumor volume measured in the clinical palpation 6 months after the treatment was(0.71±0.076)cm3,which was significantly different from(5.04±3.99)cm3 measured before the treatment(P<0.01).The breast lesions were found to be blurred or disappear during the clinical examination 1 year after the treatment.The lesions ablated well and all the patients under study achieved complete remission(CR)with an effective rate of 100%.The follow-up clinical visits of all the patients found no local recurrence or new distant metastases.Conclusion MRI guided radiofrequency ablation is a safe and effective treatment for breast cancer.