The Role Of Mi Rna In Regulating The Function And Apoptosis Of Regulatory T Cells(tTreg)

The thymic origin regulatory T cell(tTreg)plays an important role in maintaining the immune homeostasis in vivo,and the results of clinical trials show that it also protects the transplant patients from the graft versus host disease(GVHD).However,it is imminent to find a way to improve the proliferation and survival ability of tTreg as well as improve the therapeutic effect of tTreg.MiRNA is a small noncoding RNA molecule,which regulates the expression of related proteins by targeting mRNA transcription or mediating transcriptional genes.It participates in cell differentiation,death,balance and function.In this study,we hope to further investigate whether the suppressive function and viability of tTreg cells are affected by certain specific miRNA,and to improve the therapeutic potential of tTreg by elaborating related signaling pathways.We find that two signal pathways,miR-142-3p ATG16L1---FoxP3 and miR-146-5p---TRAF6---FoxP3 are critical for tTreg suppressive function and viability.In conclusion,these studies provide a new way to improve the therapeutic potential of tTreg cells by regulating the expression level of related miRNA.