Preparation Of Novel Covalent Organic Framework Composites And Their Application In The Determination Of Pharmaceutical Residue

The abuse and residues of antibiotics and anti-inflammatory drugs pose a threat to the ecological environment and human health.To provide technical support for environmental monitoring and food safety,a sensitive and selective method for rapid detection of drug residues is necessary to be developed.Therefore,this study thoroughly studied the sample pretreatment technique and high-performance liquid chromatography?HPLC?analytical methodology with non-steroidal anti-inflammatory drugs?NSAIDs?and amphenicols antibiotics as research subjects.Covalent organic framework?COF?has broad application prospects in the field of molecular adsorption and separation due to its low density,high specific surface area,controllable size and diversified functions.Integrating COF with other functional materials is a useful route to enhancing their performances and extending their applications.Hence,we designed and prepared three novel covalent organic framework composites for the extraction and enrichment of drug residues in environmental samples.The main woek of the research is as follows:In chapter two,a novel covalent organic framework/poly?styrene-divinylbenzene-glycidyl methacrylate?composite?COF@PS-GMA?was synthesized by hydrothermal synthesis method.The COF@PS-GMA was employed as the SPE sorbent for the rapid concentration of non-steroidal anti-inflammatory drugs?NSAIDs?in environmental water samples.The adsorption mechanism was studied by taking ibuprofen as an example.The results obtained indicated that the adsorption of NSAIDs by COF@PS-GMA mainly achieved by ?-? stacking interaction.The adsorption behavior can be well described by GAB model.In chapter three,nanocomposite microspheres?MICOF@SiO₂?composed of amorphous seeds and COF shells were prepared by heterogeneous nucleation and growth methods.The characterization results indicated that the MICOF@SiO₂ composite has good monodispersity and high specific surface area?322 m2 g-1?.MICOF@SiO₂ showed high adsorption capacity and selectivity for NSAIDs.The MICOF@SiO₂ was employed as the SPE sorbent for the rapid extraction and concentration of non-steroidal anti-inflammatory drugs?NSAIDs?in complex matrices.The established d-?-SPE-HPLC-UV method has low detection limit?0.3 8-2.92 ?g L-1?,high recovery?77.3%-106.6%?and stability.In chapter four,molecular imprinted ionic-COF composites?MI-IC-COF@SnO₂?were prepared from nanoflower substrate?tin dioxide?and simple building blocks?bromomethane and 1,3,5-triformylbenzene?.The results of isothermal adsorption experiments and selective adsorption experiment indicated that MI-IC-COF@SnO₂ has a large adsorption capacity and high selectivity for NSAIDs.Under the optimized experimental conditions,MI-IC-COF@SnO₂ was employed as the SPE sorbent and combined with HPLC-UV for selective detection of trace NSAIDs in environmental samples.