| Objective Sleep deprivation or sleep loss is a high risk factor for the depression,mood disorder and suicide attempts,and it is also a health killer in adolescents and young people in modern society.Sleep deprivation has been shown to affect a series of cognitive and emotional impairments,executive function is especially vulnerable to the effects of sleep deprivation.Furthermore,REM sleep and SWS sleep play different roles in the processing of cognitive function.It is less known that how does REM sleep deprivation and SWS sleep deprivation affect the executive function,and the mechanisms of sleep deprivation are still not clear.The purpose of the present study was to examine the effect of partial sleep deprivation executive functions as well as the underlying neuro-electrophysiologic mechanism,we administered classical executive function tasks to individuals after partial sleep deprivation while simultaneously acquiring EEG event related potential(ERP)data and recording affective behavioral responses.Methods Study 1.The college students subjects were dividied into three groups,control group(male =10,female =12),early night sleep deprivation group(male =9,female =9)and late night sleep deprivation group(male =8,female =10),There were no significant differences between the 3 groups in sex,age,handedness,HAMA and HAMD scores.After one night of normal sleep or sleep deprivation,the subjects were requested to perform an auditory oddball task by the approche of ERP.The ERP and standardized low-resolution brain electromagnetic tomography(s LORETA)to track MMN、P3a、P3bin the brain.Study 2.The college students subjects were dividied into three groups,control group(male =8,female =12),early night sleep deprivation group(male =10,female=11)and late night sleep deprivation group(male =11,female =10),There were no significant differences between the 3 groups in sex,age,handedness,HAMA and HAMD scores.After one night of normal sleep or sleep deprivation,the subjects were requested to perform an IGT task by the approche of ERP.The behavioural analyses,ERP and standardized low-resolution brain electromagnetic tomography(s LORETA)to compared the FRN amplitude under loss condition in three groups.Study 3.The college students subjects were dividied into three groups,control group(male =10,female =13),early night sleep deprivation group(male =11,female=11)and late night sleep deprivation group(male =12,female =10),There were no significant differences between the 3 groups in sex,age,handedness,HAMA and HAMD scores.After one night of normal sleep or sleep deprivation,the subjects were requested to perform the ACCE task with emotion regualtion.We compared the reaction times,accuracy and switch costs in different tasks between three groups in the behavioural analyses,and electrophysiological characteristics and s LORETA(DLPFC)of N1 and LPP waveforms are also compared between three groups.Results Study 1.The ERP results revealed that the amplitudes of P3 b in deviant conditions were significantly larger in REM sleep deprivation group than control and SWS sleep deprivation group.s LORETA results showed that the DLPFC area in deviant conditions were significantly activited in REM sleep deprivation group and SWS sleep deprivation group than controls.Study 2.Behaivoural data found no significant block effect between three groups.In ERP results,the FRN amplitudes were sigificantly decreased in REM sleep deprivation group and SWS sleep deprivation group.s LORETA results showed that DLPFC were significantly activited in loss conditions in REM sleep deprivation group and SWS sleep deprivation group.Study 3.There was no significant differences in the reaction times,accuracy and switch costs in different tasks between three groups in the behavioural results,while there was a significant reaction times between groups,the reaction times were significantly lower in REM sleep deprivation group and SWS sleep deprivation group than control group.There was also no difference in ERP and s LORETA results between three groups.Conclusions Study 1.REM sleep deprivation increased the P3 b amplitudes,suggested that REM sleep particularly involved in the processing of attention and working memory,and the DLPFC which involved in the processing of cold executive functions viaed compensatory mechanisms to preserve performances after sleep deprivation.Study 2.The FRN amplitude were significantly decreased after REM sleep deprivation and SWS sleep deprivation,suggested the sleep deprivation led to decreased of error detection,and the increased activition of DLPFC suggested the compensatory effect in DLPFC may be the underlying mechanisms of preserved performances in IGT.Study 3.The reaction times were faster between REM sleep deprivation group and SWS sleep deprivation group,suggested that partial sleep deprivation affected the function of alertness and attention.However,the sleep deprivation didn’t affect the switch costs both in behvioural and electroencephalograph level,suggeted that the hot exectutive function was relatively preseved in partial sleep deprivation. |
