Progressive Intermittent Hypoxia Exposure Study Based On The Altitude Health Theory

About1/6of the Chinese territory is plateau with an average altitude above3,000meters. Most of the plateaus locate in the frontier and have many nationalities, they are very important in strategic position. There is a risk of war because of Sino-Indian border dispute for a long time; Dalai Lama "Tibetan separatist" forces are in exile, who never stop separatist activities;"East Turkistan separatist" terrorist forces attack by accident, these are related to national security and border stable. It’s possible for plain garrison to highland acutely. How to ensure the health of soliders and maintain battle effectiveness have great significance.With the development of economy, tourism and mountaineering, more and more people go to plateau area. The worst disadvantage for people going from plain to plateau is the reduction of oxygen content. The unacclimatization will cause sorts of discomfort, clinical symptoms, even life danger. These problems make avoiding plateau diseases and quickly acclimatization become hot issues of plateau medical research.Before enter the plateau, one effective mean to increase the ability of hypoxia acclimatization is building the artificial hypoxia environment in plain, giving hypoxic stimulus and doing preacclimatization training. But till now, the hypoxia exposure training has no unified standard, and individual difference is significant. Therefore, the improvement study in this area has vital theoretical and practical value.This article based on the altitude health theory, focus on the progressive intermittent hypoxia exposure process. The main contents include:1. A new type of progressive intermittent hypoxia exposure (PIHE) is project and implement by the instruction of Altitude Health Theory which is given by NA. Yu Mengsun. This theory explains that the essence of the altitude reaction is hypoxia stress reaction, physiological hypoxia stress is important to acclimatization. The reason of the health problems is that the variation rate of oxygen in the environment exceed people’s own acclimatization rate. In the new PIHE process, the variation rate of simulation environment match for the one of human acclimatization. Both of them are exponent ways. 2. Two hypoxic exposure period:pre-test and post-test are set and compared. It’s the first time to prove that PIHE can improve the hypoxia acclimatization ability at4300m, including the increase of SaO2, the decrease of heart rate and breathing rate, and the improvement of sleep. Among them, the sleep time and deep sleep time are extension, deep sleep time proportion is increased, the body movement and arousal are reduced. All these quantitative indexes demonstrated the effectiveness and efficiency of new PIHE.3. It’s the first time to use sleep as an important indicator to evaluation whether the subject is within the range of physiological stress. The no-load patented mattress system and actigraph were selected to monitor the natural state of sleep. The sleep indexes with other physiological indicators, such as heart rate, blood oxygen, are combined together to identify whether subjects are in the range of physiological stress and evaluate whether the amount of intermittent hypoxic stimulus are appropriate. These give the timely feedback to ensure that the subjects will not be damaged by excessive stimulation. At the same time, the stimulation will not be too small to affect the efficiency of acclimatization.4. Try to make the evaluation of heart rate variability in the hypoxia pre-acclimatization process by nonlinear method. The changes of heart rate signal in motion and resting are analyzed by Sample Entropy. Sample entropy values of motion are higher than the values of resting. The changes of sample entropy in different heights and the same height in different periods are studied. Hypoxia preacclimatization abilitys are attempted to be evaluate by nonlinear methods.The main innovation points of this study are as follows:First, a new type of progressive intermittent hypoxia exposure (PIHE) is project and implement, which makes the variation rate of altitude in simulation environment match for the one in human acclimatization. Both of them are exponent ways. The new PIHE training reflects the guiding of altitude health theory.Second, It’s the first time to improve the PIHE training to improve sleep in4300m, questioned the "intermittent hypoxia exposure can not improve sleep".Third, It’s the first time to monitor and assess whether the stress and environmental stimulation is coordinate by sleep parameters. Through monitoring of sleep time and deep sleep time, combining with subjective feelings, heart rate and SaO2, to evaluate whether the subject is within the range of physiological stress.Forth, this paper discusses a method to evaluate hypoxia acclimatization by nonlinear method, such as Sample Entropy.