Study On TCM Constitution And Specific Plasma Protein In Phlegm-wetness Type Gout Patients

Objective To describe the gout patients constitution in traditional Chinese medicine distribution, we collected primary gout patients in Zhejiang’s6hospitals; We explored the difference protein between phlegm-wetness type gout patients with normal people by using two-dimensional electrophoresis and mass spectrometry.Methods①214cases data were collected in6hospitals of Zhejiang Province, assessing each patient’s constitutional types in Traditional Chinese Medical.②Selected8phlegm-wetness type gout patients and8health people as control; Protein was extracted from blood and two-dimensional electrophoresis, mass spectrometry was used to find the difference protein.Results①All of the primary gout patients is biased constitution; The incidence of primary gout in phlegm-wetness type accounted for21.02%, followed by Yin deficiency accounted for17.75%. Different gender, age, occupation, living environment has a relationship with gout.②There is5up-regulated protein molecules(Apolipoprotein C-Ⅱ, Zinc finger protein562, Clusterin, Apolipoprotein AI, Transthyretin) and3protein molecular (SAPS domain family, member2, LTBP3, Retinol-binding protein4) cut down, in phlegm-wetness type gout patient.Conclusion①The " Chinese constitution classification criteria " and its scale was conducted a cross-sectional study on gout patients and found that100%of primary gout crowd for biased constitution.②The incidence of primary gout in phlegm-wetness type accounted for21.02%, followed by Yin deficiency accounted for17.75%; the disease of primary gout is composed of interacting physical, living habits and environmental factors.③There is5up-regulated protein molecules in phlegm-wetness type gout patient, and3protein molecular cut down.④Phlegm-wetness type gout protein has relationship with constitution and inflammatory cytokines.