| Objective To observe the prevalence of ideal cardiovascular health(CVH) behaviors and factors in northern Chinese population, analysis the relationship between the number of ideal CVH behaviors and factors and the level of serum uric acid(UA), and investigate the effects of the number of baseline ideal CVH behaviors and factors on new hyperuricemia.Content and MethodsCollected the general clinical health examination data, laboratory examination results and blood UA level of Kailuan Group working and retired staff in 2006-2007, 2008-2009, 2010-2011 and 2012-2013. Conducted a free health examination every two years. All subjects filled out questionnaires, physical examination and blood biochemical detection. The study was performed based on Helsinki Declaration guidelines, and get the permission of Kailuan General Hospital Ethics Committee. All subjects signed informed consent. The study inclusion criteria:(1) age≥18 years;(2) have no cognitive defect, able to complete the questionnaire by oneself;(3) providing informed consent. This study exclusion criteria:(1) people with hyperuricemia in 2006-2007 year;(2) UA data missing;(3) CVH behavior and health factors data missing;(4) estimated glomerular filtration rate(e GFR) <30ml/min/1.73m2. Ideal smoking status was defined as having never smoked, ideal dietary data were defined as do not like salt, ideal physical activity was defined as moderate or vigorous physical activity for >80 minutes per week, BMI was defined as ideal if it was <25 kg/m2, blood pressure was defined as ideal if systolic blood pressure was <120mm Hg and diastolic blood pressure was <80mm Hg, without antihypertensives, fasting blood glucose was defined as ideal if <100 mg/dl and untreated, total cholesterol(TC) was defined as ideal if the untreated total cholesterol level was <200 mg/dl, Otherwise, they were defined as nonideal. Calculate the number of each person’s ideal CVH behaviors and factors, indicates with 0, 1, 2, 3, 4, 5, 6, 7 items, respectively. Hyperuricemia was defined as ≥7 mg/dl(416umol/L) in men and ≥ 6mg/dl(357umol/L) in women. Continuous variables values with skewed distribution were analyzed after log conversion. Linear regression analysis was used to calculate the relationship between the number of baseline CVH ideal behavior and factors and serum UA level in 2006-2007. Cox proportional hazard regression model was used to calculate the hazard ratios(HRs) and 95% confidence intervals(95% CI) of the risk of developing hyperuricemia according to the number of baseline ideal CVH metrics. All statistical tests were 2-sided, and P<0.05 was considered as statistically significant.ResultThe study included 77787 people, including 60951 males and 16836 females, after six years of follow-up, we identified 8,308 new onset hyperuricemia cases. The proportion of have 0-1, 2, 3, 4, 5-7 metrics CVH behaviors and factors were 15.8%, 26.7%, 31.4%, 19.9%, 6.2% in men and 4.6%, 15.5%, 27.9%, 29.9%, 22.0% in women, respectively. Every increased 1 baseline CVH behavior and factors metrics could reduce the level of serum UA 0.1mg/dl(P<0.01). After adjusting for relative risk factors, the HRs(95%CI) for hyperuricemia of population with ideal BMI and TC were 0.73(0.70-0.76) and 0.85(0.82-0.89). The HRs(95%CI) for hyperuricemia with adherence to 0-1(reference), 2, 3, 4, and 5-7 ideal CVH metrics were 1(ref), 0.95(0.89-1.01), 0.84(0.80-0.90), 0.72(0.68-0.77), 0.64(0.58-0.70), respectively.ConclusionThere were lower prevalence of the number of ideal CVH behaviors and factors in Kailuan Crowd which on behalf of North China population. Serum UA level decreased gradually with the increasing number of ideal CVH behaviors and factors; The ideal state of BMI and TC have lower hyperuricemia risk; New hyperuricemia risk decreased associated with the increasing number of ideal CVH behaviors and factors, suggested that through increase the number of CVH behaviors and factors in the broad masses of people to reduce the risk of hyperuricemia and related diseases, further improve public CVH. |
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