Analysis Of Chromosome Region In Alzheimer’s Disease And Cell Reprogramming Based On Omics Data

Transcriptome regulation in Alzheimer’s disease (AD) reflect a whole gene regulation changes in AD. Genetic studies have identified several genomic loci including chrl9p13.2 relevant to Alzheimer’s disease susceptibility. However, the functional roles of these genomic loci in AD pathogenesis require further clarification. Transcriptome as an endophenotype is critical for the understanding of disease mechanism. Here we demonstrate that chrl9p is the most significantly perturbed chromosome region in AD brain transcriptome. With dual evidence from genome and transcriptome, chrl9p likely play a special role in AD pathogenesis. As gene regulation change in AD is significant, the cell state changes. So next we decided to analyze the mechanism in cell fate transition, and try to provide some new ideas in the treatment of AD. Since the discovery of Yamanaka factor in inducing somatic cells to pluripotency, induced pluripotent stem cells (iPSC) hold great promise in the field of regenerative medicine, especially the treatment of diseases like Alzheimer’s disease, stem cells also provide a perfect model in cell fate analysis. So in this part, we analyze the whole gene regulation in reprogramming in different omics data. On one hand, this analysis can help improve the iPSC efficiency and application; on the other hand, it may provide possible hints in neural cell transition through gene regulation.