| About 20%-30% of people suffer from infertility problems in the worldwide, the assisted reproductive technology (ART) plays an important role in solving this problem. Women with uterine factors infertility (UFI) who due to absence of the uterus or presence of a nonfunctional uterus currently have no option of having children, accounted for about 3%-5% of the general population. However, the existing clinical application of ART could not make those UFI patients breed offspring. Previous studies indicated that uterine transplantation could overcome UFI problems. Uterus transplantation(UT) is an important option for women with UFI that could graft a functional uterus and to delivery a children. Based on recent developments in transplantation techniques and immunology,15 uterus transplantation have been performed in humans, including 11 cases of survival,four healthy babies have been born from this cohort and additional patients are pregnant. The cause of pregnancy failures may be related to decreased vascular plasticity, placental defects, and loss of innervation, that may negatively affect the pregnancy potential in uterus. In the past 15 years, UT studies have been performed in many different animal species, such as rabbits, pig and nonhuman primate. The uterine vascular and pelvic size of pig was similar to that of human, however, because of large volume, vascular anastomosis difficulty, research for uterine transplantation in swine was not very much. In order to explore the whole UT process, we carried out UT by swine animal model in this paper. Aiming to provide necessary experimental basis and clinical support for human uterus transplantation. Therefore, UT experiment in swine has great significance for future overcoming the UFI female infertility. |
