Effects Of Nordic Walking Interventionon Abdominal Adiposity, Hepatic Fat Contentand Serum Lipidof Postmenopausal Women With Pre-diabetes And Non-aleoholic Fatty Liver Disease

Objective The aim of the study was to investigate the impact of35 weeksnordic walkingintervention on body composition, abdominal adiposity, liver fat content and glycolipid metabolic inpostmenopausal women with prediabetes and non-alcoholic fatty liver disease(NAFLD).Methods 1. Subjects: 45 postmenopausal women with pre-diabetes and non-alcoholic fatty liver disease from Yangpu District were includedas subjects and randomized into nordic walking group(NW group)andcontrol group(CON group).Among them, 17 in the NW groupand 14 in the Con group completed the intervention. All the subjects were voluntary and signed the information consents. 2. Intervention: Nordic walking as the main mode of aerobic exercise with stretching exercises Tai Chi exercise as preparation and finishing activities. All the subjects took exercise in the sports venues together. The intensity of the exercise increased from 60% VO2 max to 75% VO2 max, the time of the exercise increased from 45 minutes to 60 minutes, the frequency of the exercise added from 3 times a week to 5times a week for 8.6 month. 3. The test measures: Dual-energy X-ray Absorptiometry was used to check the body body composition, abdominal adiposity(subcutaneous adipose tissue,SAT; retroperitoneal adipose tissue, RAT; intraperitoneal adipose tissue, IAT; and visceral adipose tissue, VAT) at the T10, L2-L3, L4-L5 levels of vertebrae and total rangion from the tip of the xyphoid to L5) was measured by MRI, 1H Magnetic Resonance Spectroscopy was used to detectedhepatic fat content(HFC). Serum FFA, LDL, TC and TGwere also observed before and after the intervention.Results 1. After35-week intervention, cardio-pulmonary function inprovedin NW group and the weight, Android fat mass, Gynoid fat mass, Fat mass of whole bodyin NW group decreased significantly than before(p<0.05).FFM and Lean mass in CON group decreased significantly than before(p<0.05).2. The total SAT, RAT, IAT & VAT; SAT, RAT, IAT & VAT of T10 level; IAT and VAT of L4-5 level in NW group were all decreased significantly(p<0.05) after 8.6 month. Thebetween-group difference in NW vs CON group of total SAT; SAT, RAT, IAT & VAT of T10 level were significant(p<0.05). 3. After35-week intervention, the hepatic fat content of NW group decreased significantly than before(p<0.05).Serum FFA, LDL, TC level of postmenopausal women in NW group was decreased significantly(p<0.05). There is nosignificantdifference in TC level. 4. The change after intervention of Total fat content has highly correlatedwith HFC(R>0.7, p<0.05). Android, Gynoid fat content, IAT in L2-L3 & L4-L5 level, VAT L4-L5 level, serum TC & TG level has moderately correlated with HFC(0.4≤R<0.7,p<0.05).Conclusion 1. NW intervention can reduce body weight, Android fat mass, Gynoid fat mass, Fat mass of whole body of postmenopausal women with pre-diabetes and NAFLD.NW intervention can delay the decline of the FFM and leanmass of postmenopausal women with pre-diabetes and NAFLD. 2. NW intervention can reduce the total SAT, RAT, IAT & VAT mass; the mass of SAT, RAT, IAT & VAT of T10 level; IAT and VAT of L4-5 level.Nordic walking can prevent the accumulation of fat around the liver, but it can not reduce the mass of SAT, RAT, IAT & VAT of L2-L3 level. 3. NW intervention can effectively improve the HFC and can reduce serum FFA, LDL, TC level of postmenopausal women with pre-diabetes and NAFLD. 4. The effect of NW intervention on Total, Android &Gynoid fat content, IAT in L2-L3 & L4-L5 level, VAT L4-L5 level, serum TC & TG level has moderately correlated with HFC.