Gastric Cancer:Detection And Frequency Of Metastasis V In Mesogastrium

Background: We recently proposed a novel type of tumor metastasis designated as metastasis V in gastric cancer. Metastasis V is defined as the existence of cancer cells in the perigastric adipose tissue of mesogastrium.Objectives:The main aim of the present study was to design a method to detect metastasis V, seconderly to clarify the relationship between this form of cancer spread, clinicopathologic findings of metastasis VMethods:74patients of curative gastric cancer underwent Laparoscopic D2gastrectomy+CME, specimen subjected to large cross sectional tissue analysis of mesogastrium. Statistical analyses were performed by SPSS version17.0. Descriptive data were presented as mean±SD. The chi-square test and Fisher’s exact test were used for comparisons between two groups. Data were considered statistically significant at p≤0.05.Results:it is showed that metastasis V was detected in1of40(2.5%) patients with early gastric cancer,8of34(24%) patients with advanced gastric cancer. The mean distance of metastasis V from gastric wall was approximate2.6cm. Metastasis V was closely associated with tumor invasion depth and the numbers of positive lymph node metastasisConclusions:These findings indicate that by using whole-sectional analysis metastasis V can be detected in the mesogastrium of gastric cancer patient, also suggest it may be risk factor for local-regional recurrence in post radical surgery treatment. Complete mesogastrium excision (CME) is crucial important while integrity of the mesogastrium strictly preserved.