Control Of Portal Venous Flow By Portal Vein Banding Prevent Post-operative Liver Falure

Background and ObjectivesHepatectomy is a best approach to liver tumor treatment.The risk of post-operative liverfalure is the central probleme after major heptectomy due to the “small for sizesyndrome”.Excessive portal blood flow compare to the remnant liver may result in severeliver falure. Reduction of portal flow can prevent post-operative liver falure by derivationof the portal flow or splenectomy.It is not clear whether portal vein bangding can reduceportal flow to prevent post-operative liver falure or not.The research aim to explore theimpact on liver function by the method and investigate the mechanism to preventpost-operative liver falure.Methods and Materials（1） Establish stable and credible model of post-operative liver falure in SD rat.（2）Establish the data of portal venous flow and portal pressure after marginal hepatectomy inSD rat.（3）Measure and record the value of portal venous flow in the cases of differentdegree of portal veinbanding and calculate the post-hepatectomy survival rate（.4）Analysisthe machnism of preventing post-operative liver falure by liver function test and liverpathological reseach.Results(1) resection of the relevant liver lobes by placing4–0suture ties most proximally to theirorigin can Establish stable and credible model of post-operative liver falure in SD rat.(2)The value of portal venous flow per liver volume can increase by increasing hepatectomyproportional.The values of portal venous flow can reach4times as the baseline values after90%hepatectomy.（3）Portal vein banding can ruduce the excessive portal venousflow,increase flow of hepatic artery,protect function of remnant liver and hardly aggravateintestine congestion（.4）Control of portal venous flow by portal vein banding can improvethe survival rate after marginal hepatectomy in SD rat. ConclusionsOur results suggested that portal vein banding can ruduce the excessive portal venous flowafter marginal hepatectomy to reduce the risk of post-operative liver falure in SD rat.