| Temporal lobe epilepsy(TLE) patients can cause structural damage outside the brain and obstacle of cognitive function because repeated, long-term to temporal lobe seizures. Studies have confirmed that TLE patients often have abnormal brain structure and function in the epileptic foci and foci outside. Structural changes are not only confined to the temporal lobe, including the amount, parietal lobe, thalamus, cerebellum and limbic system and other structures. Numerous studies have found that patients with epilepsy have damage of default network and pay attention network. This suggests that TLE is a brain damaged diseases due to caused by multiple network. We study right TLE patients’s network structure and function through the magnetic resonance. Explore the correlation between function connection and structure connection, Reveal brain network damage of rTLE patients, and further reveal the impaired foundation of rTLE patients.Study one:[Objective] Using independent component analysis (ICA) method to explore rTLE patients functional connectivity (FC) change of the network and inter network in resting state. [Materials and methods] Select rTLE 16 patients. In addition, select 16 age-matched healthy volunteers as a control group. Using PHILIPS Achieva 3.0T magnetic resonance scanner to scan high-resolution 3D and T1 anatomy mages and resting state fMRI scan. Preclude the use of Matlab-based SPM8 and DPARSF to preprocesse resting state fMRI data, the process comprising:time correction, head movement correction, spatial normalization, and spatial smoothing (6x6x6mm3).Using ICA to extract resting-state brain networks (RSNs), to obtain four RSNs. Compare the difference intensity of each RSN function connection between rTLE group and normal control group. The analysis of functional connectivity between net-works based on the ICA preprocessing filtering and removal of covariates. Calculated the Pearson correlation coefficient of mean time sequences of the individual every RSNs, and Fisher’s Z transform. Finally all subjects with age and gender as a covariate, had statistical significance in the network functional connectivity between groups were compared. [Results] compared with the normal control group, functional connections of rTLE patients significantly increased in brain areas, including:aDMN temporal lobe, LFP of the left temporal lobe. PDMN right cingulate gyrus, VN right occipital lobe from gutter. functional connections of rTLE patients also exist significant reduction in brain areas, including:aDMN in the prefrontal frontal gyrus, pDMN right precuneus and VN left occipital lobe, LFP left occipital lobe. Compared with the normal control group, functional connectivity of rTLE patients between pDMN-rFPN (P =0.039) shows decreased. Function connection between aDMN-pDMN (P= 0.018) reducing positively,and functional connectivity between AN-rFPN (P 0.007) and between pDMN-dSMN (P=0.032) was negative decreased. [Conclusion] 1, Functional connections of rTLE patients significantly increase in brain areas, including:aDMN temporal lobe, LFP of the left temporal lobe. pDMN right cingulate gyrus, VN right occipital lobe from gutter.2, functional connections of rTLE patients also exist significant reduction in brain areas, including:aDMN in the prefrontal frontal gyrus, pDMN right precuneus and VN left occipital lobe, LFP left occipital lobe.3, functional connectivity of the default network network of rTLE patients is increased; frontoparietal network and the front of the default network network functional connectivity is reduced. In patients with rTLE after the default network respectively with the default network, change the right frontoparietal network is connected between the lower positive function.Study 2:[Objective] application of functions connected magnetic resonance (fcMRI) and independent component analysis (ICA), diffusion tensor imaging (DTI) and other magnetic resonance imaging of normal people and rTLE patients default connection network (DMN) resting state functional and structural connectivity to study of rTLE patients with DMN resting state functional connection and the connecting structure changes and their mutual relationship. [Materials and methods] Select rTLE 16 patients. In addition, select 16 age-matched healthy volunteers as a control group. Using PHILIPS Achieva 3.0T magnetic resonance scanner to scan high-resolution 3D and T1 anatomy mages and resting state fMRI scan, DTI. Get common image, rfMRI data and DTI data for the diagnosis of. The data are processed by the software dparsf, rest, mica, TrackVis etc. GET schematic of functional and structure connections of DMN function and mean fractional anisotropy (mFA),mean diffusivity (MD),average fiber beam length (ML). The resulting values were statistically analyzed. [Results] there functional connectivity abnormalities in the region of weakening of the right thalamus, mPFC increased functional connectivity, and PCC, mTLs function connection weakened. Between the three ROI, the function between the rTLE group PCC-mPFC PCC-mTL connection strength than in the control group were significantly decreased (0.674+0.149 vs 0.769+0.077), and the function between the PCC-mTL between PCC-mPFC connection strength decreased significantly (0.343+0.145 vs 0.532+0.135), the average time on the reaction function connection strength of the correlation coefficient r values were two sample t-test and between between rTLE group PCC-mPFC PCC-mTL that values were significantly lower than the control group, and the difference has statistical significance (P< 0.05). The value of ML, mFA, MD between the two groups, were two sample t test, compared with normal control group mFA decreased between rTLE group PCC-mPFC and PCC-mTL, and the difference has statistical difference (P< 0.05); values of the MD rTLE group PCC-mPF between higher than that of the normal control group, with significant difference (P< 0.05). [Conclusion] the rTLE patients exist by default network of abnormalities, including decreased functional connectivity in the region including PCC and mTL (R/L), functional connectivity in the mPFC regions including enhanced, indicating that the rTLE patients with DMN functional remodeling or compensation; the right thalamus appear to be functional connectivity abnormalities in the region of weakening, related to and the brain functional reorganization. rTLE patients connectivity in the DMN and mTL-PCC mPFC-PCC structure connection and function connection was higher than that of the normal control group were weakened and functional connectivity and there is a correlation structure is connected between, It is indicated that the functional connectivity of rTLE patients with the default network has the structural basis, which is the structural connection change. |
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