Polymorphisms In UGT2B17and UGT2B4Associated With Susceptibility To Pancreatic Cancer

Objective:The UGT2B17and UGT2B4are important bodies of the second phase metabolic enzymes involved in the metabolic processes of a variety of endogenous and exogenous substances. The UGT2B17and UGB2B4gene polymorphisms can affect the level of mRNA transcription, thereby affecting its metabolic activity. This study aimed to explore the UGT2B17and UGB2B4gene polymorphisms and more state and the Han population of pancreatic cancer risk relationship.Methods:The study includes406cases of pathologically confirmed patients with pancreatic cancer and1579cases of normal control genomic DNA extracted from peripheral blood lymphocytes. Specific primer PCR method to detect the UGT2B17gene deletion polymorphism in different populations. Flight mass spectrometry method to detect UGT2B4gene polymorphism genotyping. The multivariate logistic regression analysis to calculate the ratio of odd ratio (OR) and its95%confidence interval (confidence interval, CI), the association of the UGT2B17and UGT2B4gene genotype and pancreatic cancer susceptibility.Results:The UGT2B17gene del/del, del/ins and ins/ins genotype distribution in patients with pancreatic cancer in frequency:72.9%,24.0%and3.1%, the distribution of frequencies in the normal control population, respectively:66.6%,30.7%and2.7%. The genotype distributions of the case and control groups are in line with the Hardy-Weinberg equilibrium. Multivariate logistic regression analysis showed that, compared with UGT2B17gene del/del genotype, carrying the del/ins genotype suffering from a significant reduction in the risk of pancreatic cancer, the OR was0.77(95%CI=ICC=0.60to0.99; P=0.04), and carry ins/ins genotype does not increase the risk of pancreatic cancer (OR=0.98,95%CI=0.51-1.89; P=0.96); gender stratified results showed a similar association in women. The UGT2B4gene rs1131878Câ†'T transition is associated with increased risk of pancreatic cancer, compared to the with CC genotype, carrying the CT genotype pancreatic cancer risk increased1.39-fold (95%CI=1.09-1.77, P=0.007), with TT genotype the risk of pancreatic cancer increased to2.97fold (95%CI=1.24-7.08, P=0.014). Compared to the UGT2B4gene rs3822179AA genotype, the risk of pancreatic cancer carry AC genotype reduced approximately20%(OR=0.80,95%CI=0.67-0.95, P=0.011), while carrying the CC genotype the risk of pancreatic cancer is not significantly lower (OR=0.77,95%CI=0.52-1.14, P=0.191).Conclusion:The UGT2B17and UGT2B4gene polymorphisms may be associated with the Han pancreatic cancer risk.